Flavors and fragrances Flavors and fragrances are substances that stimulate the senses of TASTE AND SMELL. With the exception of the four primary taste sensations--sweet, bitter, salty, and sour--flavor characteristics are the result of our perception of odor; the difference between a flavor and a fragrance is in large part only a semantic distinction. Thus, a substance that provides an odor in PERFUMES may also be used to add flavoring to a food. Most natural flavorings and fragrances are derived from plant substances--either from the aromatic, volatile vegetable oils known as ESSENTIAL OILS, or from the nonvolatile plant oils called RESINS. The aromatic substances derived from flowers, from herbs and spices, and from animal secretions (musk and ambergris, for example) are usually costly and limited in supply. Over the past century, success in reproducing some of these substances synthetically has created a new industry that today produces hundreds of flavors and fragrances for use in food, perfumes, and other products. Some fragrant substances are relatively easy to synthesize. Vanillin, the aromatic ingredient in vanilla, can be readily reproduced by synthesis, as can benzaldehyde, the principal component of the odor of wild cherry. Many flavors and fragrances, however, have scores, if not hundreds, of components that contribute to their aroma. Only recently has it become possible to separate these components, using gas chromatography, and to determine their chemical structure with the aid of spectroscopy. Once the chemical identity of the components is known, it is often possible to make them synthetically. The search for new synthetics continues, and some of the most complex, among them the substances that produce the aroma of coffee, have still not been duplicated satisfactorily. Many of the chemical compounds making up these synthetic materials are identical to those found in nature and are as harmless, or harmful, as the naturally derived essences. New products with unknown toxicology must be tested for safety, and, when used in foods, must be accepted as safe by the U.S. Food and Drug Administration. The availability of synthetic flavors and fragrances makes possible a large variety of products, from inexpensive beverages, to perfumed soaps, to used cars with an applied "new car odor." To cite two examples: the chemical compound B-phenylethyl alcohol, a vital ingredient in any rose fragrance, may be extracted from natural rose oil at a cost of thousands of dollars per kilogram; or an identical, synthetic substance can be made at one percent of this cost. Synthetic musk is chemically different from the musk derived from animals, but its odor effects are similar, and again the cost is a small fraction of that for the natural extract, and the quantities available are basically unlimited.